Establishing Evidence for Use of Appropriate Medicines in the Operating Room

Various issues related to clinical use of medicines remain unclear, and pharmacists are expected establish evidence for appropriate medicines. The present review summarizes our findings from three areas research regarding the in operating room: 1) We evaluated extent extravasation injury due thiopental (2.5 mg/100 μL) propofol (1.0 at macroscopic histopathologic levels a rat model. Thiopental, which causes tissue necrosis, can be classified as vesicant, an irritant. Moreover, warming strongly exacerbated degeneration or necrosis induced by thiopental. 2) cytotoxicity povidone-iodine solution (PVP-I) ophthalmic that polyvinyl alcohol-iodine (PAI) was compared using human corneal epithelial cell line. Despite exhibiting equivalent antiseptic effects, PVP-I diluted 16-fold greater than PAI 6-fold. After inactivation iodine, persisted; therefore, avoid damage, antisepsis should achieved with PAI. 3) stability 1 μg/mL adrenaline when used intraocular irrigating maintain pupil dilation evaluated. mixing 6 h, concentration 65.2% (pH 8.0) initial concentration. low sodium bisulfite could have caused reduction. Our results suggest irrigation containing prepared just prior surgery.